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PHYSIOLOGIC ANTIOXIDANT AGENTS AND OXIDATIVE MODIFICATION OF LDL

$321,374M01FY2001RRNIH

University Of Texas Sw Med Ctr/Dallas, Dallas TX

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Abstract

Recent data suggests that in addition to lowering LDL-cholesterol, prevention of its oxidative modification might retard the progression of the atherosclerotic lesion. The specific aspects that will be addressed include the effect of Vitamin E and combined antioxidant therapy on the biochemical changes of Oxidized LDL (lipid peroxide content, electrophoretic mobility, and formation of conjugated dienes) and its degradation by human macrophages.

View original record on NIH RePORTER →