INTRAVENOUS CCI 799 GIVEN TO PATIENTS W/ ADVANCED SOLID TUMORS

$0M01FY2001RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

Investigators

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Abstract

Our hypothesis is that CCI-779 is a potent and effective antitumor agent. The specific aims of the study are to determine the safety and tolerability and identify the maximum tolerated dose (MTD) of CCI-779, given intravenously (IV) once daily for 5 days, every 2 weeks, in patients who have advanced solid tumors and who are not taking anticonvulsants; to determine the safety and tolerability, and identify the maximum tolerated dose of (MTD) of CCI-779, given intravenously (IV) once daily for 5 days, every 2 weeks in patients who have recurrent gliomas or brain metastases from other tumors and who are receiving anticonvulsants; to determine the preliminary pharmacokinetics of CCI-779 on this schedule; and to obtain preliminary information on the anti-tumor activity of CCI-779.

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