Mathematically Rigorous Results In Sequence Matching.

National Library Of Medicine

Investigators

Linked publications, trials & patents

Abstract

The NCBI CoreTools now contains code from us, code that calculates to practical accuracies, and in less than 1 sec, all parameters of the modified Gumbel distribution (the Gumbel scale parameter, , pre-factor k, and finite-size correction). The BLAST group plans has used our faster calculations to generate the modified Gumbel parameters for several new DNA scoring schemes. Our collaboration with Dr. Martin Frith has extended our methods to next-generation sequence matching, including frameshifts in DNA, a subject of relevance to the NCBI BLAST services. In a practical test of our methods, our frameshift statistics found many novel human pseudogenes.