PHASE I STUDY ON INTRATHECAL MAFOSFAMIDE

$0M01FY2001RRNIH

Baylor College Of Medicine, Houston TX

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Abstract

The goals of this study are to determine the qualitative and quantitative toxicity of intrathecally administered mafosfamide in a limited dosage escalation schedule, to define a safe dose of intrathecally administered mafosfamide which can be recommended for subsequent Phase II studies, and to determine the CSF pharmacokinetics of intrathecally administered mafosfamide.

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