Role of allergen-driven epithelial genes in asthma pathogenesis

$384,306U19FY2013AINIH

Cincinnati Childrens Hosp Med Ctr, Cincinnati OH

Investigators

Linked publications, trials & patents

Paper 39189791 Paper 39110589 Paper 38645179 Paper 38564302 Paper 38555071 Paper 38405748 Paper 38335270 Paper 38183988 Paper 38008216 Paper 37745430 Paper 37699081 Paper 37650296 Paper 37646328 Paper 37490338 Paper 37391018 Paper 36878383 Paper 36863390 Paper 36794967 Paper 36719906 Paper 36592704 Paper 36209816 Paper 36002647 Paper 35981904 Paper 35860216 Paper 35660376 Paper 35606385 Paper 35595084 Paper 35576187 Paper 35472002 Paper 35081436 Paper 34838883 Paper 34815391 Paper 34673050 Paper 34635581 Paper 34380050 Paper 34271060 Paper 34111451 Paper 33721370 Paper 33646859 Paper 33446330 Paper 33446329 Paper 33382170 Paper 33289661 Paper 33175399 Paper 33052338 Paper 32853786 Paper 32796837 Paper 32665400 Paper 32640045 Paper 32572240 Paper 32526311 Paper 32461336 Paper 32389591 Paper 32378146 Paper 32320735 Paper 32302785 Paper 32201305 Paper 32102851 Paper 32035158 Paper 31977951 Paper 31922608 Paper 31910986 Paper 31703761 Paper 31610053 Paper 31470287 Paper 31132551 Paper 31089182 Paper 31051184 Paper 30996235 Paper 30958799 Paper 30855279 Paper 30830718 Paper 30741719 Paper 30554722 Paper 30527929 Paper 30108214 Paper 29980278 Paper 29936100 Paper 29875205 Paper 29790577 Paper 29672914 Paper 29669943 Paper 29654071 Paper 29590301 Paper 29535264 Paper 29475849 Paper 29413333 Paper 29378287 Paper 29242581 Paper 29157947 Paper 29129581 Paper 29063212 Paper 29048518 Paper 29046486 Paper 29029802 Patent 9928344 Patent 9803244 Patent 9624545 Patent 9345763 Patent 9260756

Abstract

Allergic diseases continue to pose a significant public health burden in modernized societies. Although the etiology of allergic diseases is unknown, they are thought to develop as a result of aberrant Th2 immune responses in genetically susceptible individuals. Despite this recognition, the factors driving Th2-mediated immune responses have remained elusive. Our preliminary data suggests the novel paradigm that allergen exposure induces epithelial cell injury which results in the release of an epithelial-derived factor, trefoil factor 2. Tff2, in turn induces the release of the

View original record on NIH RePORTER →