HUMAN CEREBRAL GABA METABOLISM STUDIES IN VIVO WITH MR SPECTROSCOPY

$0M01FY2001RRNIH

Yale University, New Haven CT

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Abstract

We propose to study brain glutamate and GABA turnover in patients with epilepsy using combined lH and 13C NMRS. The responses to two novel anti-epileptic drugs will serve as probes to clarify the metabolic response to increased levels of GABA.

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