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ROLE OF BRADYKININ IN REGULATION OF RENIN RELEASE

$0M01FY2001RRNIH

Vanderbilt University, Nashville TN

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Abstract

The renin release is mediated in part by bradykinin and antagonism of bradykinin w/a B2 receptor antagonist will abolish the renin response to furosemide. SPECIFIC AIMS: To determine the renin response to furosemide in health volunteers in the presence and absence of icatibant (HOE-140), a bradykinin receptor antagonist. To determine the effect of bradykinin antagonism on urinary prostacyclin metabolite concentrations.

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