QUANTIFICATION OF BRAIN OXIDATIVE DAMAGE IN ALZHEIMER'S DISEASE PATIENTS

$0M01FY2001RRNIH

Vanderbilt University, Nashville TN

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Abstract

That CSF F2-isoP concentrations, F4-neuroP concentrations, or both may be quantitative biomarkers of oxidative damage to brain in Alzheimer's Disease (AD). SPECIFIC AIMS: (1)To determine the specificity of elevated CAF F2-isoP and F4-neuroP concentrations for AD versus other age-related dementing illnesses (Pursuit of this aim does not involve the CRC). (2)To determine if F2-isoP and F4-neuroP concentrations in CSF from living patients correlate w/measures of AD severity, progression, and response to therapeutics.

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