CYPROHEPTADINE ON CIMETIDINE INDUCED PROLACTIN IN SCHIZO

$0M01FY2001RRNIH

Vanderbilt University, Nashville TN

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Abstract

Cimetidine-induced prolactin (PRL)secretion is mediated via the 5-HT2A mechanism. Atypical antipsychotic drug w/5-HT2A antagonism, will block cimetidine induced PRL secretion in patients w/schizophrenia. Cyproheptadine, a 5-HT2A/2C receptor antagonist w/antihistamine properties, will block cimetidine-induce PRL secrection in normal controls. The cimetidine- induced PRL response is blunted in patients w/schizophrenia compared to normal controls.

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