LIVE RECOMBINANT CANARY POX ALVAC HIV IN HIV 1 UNINFECTED ADULT VOLUNTEER

$0M01FY2001RRNIH

Vanderbilt University, Nashville TN

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Abstract

Evaluate the safety and immunogenicity of ALVAC-HIV(vCP205), a recombinant canarypox vector into which the following two gene segments have been inserted: HIV-1 envelope gp120(strain MN) linked to the transmembrane portion of HIV-1 gp41(strain LAI) and the HIV-1 LAI genes encoding the entire gag protein and the protease portion of the pol sequence. The vaccine is to be given to healthy, HIV-1 uninfected adult volunteers.

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