2-hydroxy-4-methoxybenzophenone in laboratory animals for the National Toxicology

Battelle Centers/Pub Hlth Res & Evaluatn, Columbus OH

Investigators

Abstract

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of 2-hydroxy-4-methoxybenzophenone (HMB), following dietary exposures. HMB is used in sunscreens. 2-Year chronic toxicity and carcinogenicity studies of HMB are in the in life phase. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the HMB study, rats were exposed perinatally prior to the 2-year study; this study is in the in life phase. Standard studies conducted in mice are in the histopathology/report writing phase. Keywords: toxicity, carcinogenicity, diet, perinatal, 2-hydroxy-4-methoxybenzophenone