PHASE I STUDY OF ORAL BCX 34 IN PATIENTS W/ T CELL MALIGNANCIES

$0M01FY2001RRNIH

Vanderbilt University, Nashville TN

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Abstract

Determine the toxicity produced by the oral administration of BCX-34 administered orally to patients who have T-cell malignancies which have failed light therapy or chemotherapy. We hypothesize that the development and use of VCX-34 will suppress the activity of mammalian purine nucleoside phosphorylase (PNP) which is directly involved in the proliferation of human T-cells.

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