Pharmacokinetic interactions: digoxin /grapefruit juice

$0M01FY2001RRNIH

University Of California San Francisco, San Francisco CA

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Abstract

Our approach to investigate potential P-glycoprotein-related grapefruit juice-drug interactions, based upon categorization into P-gp substrates and non-P-gp substrates, clearly revealed that grapefruit juice exposure has a considerable, activating impact on the secretory efflux of P-gp substrates. We therefore suspect, and will begin to test in this application, that the activating effect of grapefruit juice on P-glycoprotein partially counteracts the CYP3A-inhibitory effects of grapefruit juice.

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