Identify the strategies that tissues use to control growth

$509,723P50FY2013GMNIH

University Of California-Irvine, Irvine CA

Investigators

Linked publications & trials

Paper 39677714 Paper 39677598 Paper 39575928 Paper 39544498 Paper 39508736 Paper 39433621 Paper 39147742 Paper 39100726 Paper 38924582 Paper 38915633 Paper 38825174 Paper 38517270 Paper 38292607 Paper 37873302 Paper 37662399 Paper 37248279 Paper 36733607 Paper 36334265 Paper 35978440 Paper 35912523 Paper 35701434 Paper 35490296 Paper 35442034 Paper 35354026 Paper 34342808 Paper 34236056 Paper 34059671 Paper 33797066 Paper 33558268 Paper 33328229 Paper 33140960 Paper 32948857 Paper 32574592 Paper 32475606 Paper 32300614 Paper 32235070 Paper 32156820 Paper 32075905 Paper 32045203 Paper 32034817 Paper 31837080 Paper 31787778 Paper 31769463 Paper 31747251 Paper 31318476 Paper 31194290 Paper 31015253 Paper 30930170 Paper 30918123 Paper 30851407 Paper 30649861 Paper 30539716 Paper 30450444 Paper 30428314 Paper 30421535 Paper 30367883 Paper 30295346 Paper 30219101 Paper 30211018 Paper 30190551 Paper 30082477 Paper 29885356 Paper 29853637 Paper 29847666 Paper 29572236 Paper 29527134 Paper 29506130 Paper 29501424 Paper 29497351 Paper 29486740 Paper 29440510 Paper 29430078 Paper 29415263 Paper 29412191 Paper 29382395 Paper 29348472 Paper 29335600 Paper 29242135 Paper 29203124 Paper 29115333 Paper 29089371 Paper 29026113 Paper 28989185 Paper 28919480 Paper 28855971 Paper 28835608 Paper 28740156 Paper 28723574 Paper 28695824 Paper 28681151 Paper 28671940 Paper 28623341 Paper 28539409 Paper 28536277 Paper 28511648 Paper 28510061 Paper 28440378 Paper 28396345 Paper 28355163 Paper 28337978

Abstract

THEME B: CONTROL OF GROWTH AND MORPHOGENESIS (Anne Calof, Theme Leader) I Epithelia are organized sheets of cells that play a central role in determining the sizes and 3D architectures of our organs. Ducts, lobules, buds, alveoli, even stem cell niches, all take their form through the actions of epithelia during development. During the past grant period, through studies of the mouse olfactory epithelium OE), we made great progress in understanding how negative feedback control of self-renewal is used to achieve robust size homeostasis and rapid regeneration [19-24]. This strategy solves some of the problems that epithelia face, but not others, such as control of planar expansion; creation of morphogenetic units; and protection of cell lineages from accumulated damage. Here we take up these questions, returning to the OE, but also introducing two new systems: the mouse intestinal epithelium (IE) and the C. elegans gonad.

View original record on NIH RePORTER →