PHASE I TRIAL OF ADENOVIRAL VECTOR DELIVERY OF THE HERPES SIMPLEX THYMIDINE

$0M01FY2001RRNIH

Mount Sinai School Of Medicine Of Cuny, New York NY

Investigators

Linked publications & trials

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Abstract

The specific aims of this proposal are to study in a Phase I trial the toxicity of escalating doses of recombinant adenoviral vector expressing the herpes simplex thymidine kinase gene (ADV-tk) administered by percutaneous intratumoral injection of metastatic hepatic tumours followed by the intravenous administration of a fixed dose of ganciclovir (GCV).

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