IDIOTYPE VACCINATION WITH MURAMYL DIPEPTIDE IN LYMPHOMA

$0M01FY2001RRNIH

Stanford University, Stanford CA

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Abstract

This trial is designed to test the safety and immunogenicity of a vaccine consisting of idiotype protein plus the chemical adjuvant SAF-1 in patients with low-grade B-cell lymphoma. The long-term goal of this study is to develop a vaccine therapy which will induce a clinically effective immune response. The vaccine is produced on a custom basis from each patient's tumor cells hybridoma techniques. The SAF-1 adjuvant an oil-in-water emulsion plus the immunostimulant muramyl dipeptide.

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