Study of Hyperkyphosis, Exercise and Function - SHEAF

University Of California, San Francisco, San Francisco CA

Investigators

Linked publications & trials

Abstract

DESCRIPTION (provided by applicant): Hyperkyphosis is an accentuated forward thoracic curvature that is an independent risk factor for impaired physical function, reduced quality of lif, and other serious adverse health consequences. Although hyperkyphosis commonly affects older individuals, there are currently no evidence-based treatments to prevent or treat it. However, there is strong preliminary evidence that kyphosis-specific strengthening exercises done regularly over a three month period can improve kyphosis and physical function in older hyperkyphotic persons. Therefore, to build upon these preliminary findings, we now propose to conduct a randomized, controlled trial among 100 men and women aged 60 or older with hyperkyphosis to test if an exercise intervention that includes kyphosis-specific spinal muscle strengthening exercises compared to a non-specific stretching control will improve kyphosis and physical function assessed by the modified Physical Performance Test and gait speed. We will also assess whether the exercise intervention improves secondary measures of physical function and health related quality of life. Finally, to gain a better understanding of the mechanisms by which kyphosis-specific exercises may affect kyphosis and physical function, we will specifically measure spinal muscle strength via the Biodex and perform CT scan measurements of spinal muscle density to assess how muscle changes may mediate the effects of change in kyphosis on physical function. To date, exercise trials have used lower extremity strengthening exercise to improve physical function in older adults with demonstrated success, but none have targeted spinal strengthening, per se. Our specific focus on decreasing spinal hyperkyphosis represents a fundamental paradigm shift in exercise intervention strategies. This proposal is timely as the number of affected persons with hyperkyphosis is projected to increase with the aging population and currently, there are no standard prevention or treatment strategies to offer these patients. To address this important health problem and the National Institute of Aging's objective of maintaining physical functional ability in older persons, we have assembled an experienced team that includes experts in the design and conduct of randomized controlled trials, musculoskeletal medicine and physical therapy, geriatrics and biostatistics - a truly collaborative effort across multiple disciplines of expertise.