Biomarker Core

$72,930P50FY2013DKNIH

Cincinnati Childrens Hosp Med Ctr, Cincinnati OH

Investigators

Linked publications & trials

Paper 39592775 Paper 38172172 Paper 38151013 Paper 38106571 Paper 38025209 Paper 37365422 Paper 37293022 Paper 37010559 Paper 36821787 Paper 36715772 Paper 36482770 Paper 35933485 Paper 35834274 Paper 35568436 Paper 35234208 Paper 35006358 Paper 34371091 Paper 34307989 Paper 34279063 Paper 34003706 Paper 33843271 Paper 33789950 Paper 33615068 Paper 33599997 Paper 33426398 Paper 33411068 Paper 33115917 Paper 32948644 Paper 32679151 Paper 32620676 Paper 32450046 Paper 32289161 Paper 32283087 Paper 32257978 Paper 32202936 Paper 31985750 Paper 31846120 Paper 31713215 Paper 31461442 Paper 31439924 Paper 31286243 Paper 31128770 Paper 31017009 Paper 30940863 Paper 30906192 Paper 30903163 Paper 30855196 Paper 30676490 Paper 30569313 Paper 30285245 Paper 30159624 Paper 30088425 Paper 30035208 Paper 30022312 Paper 29993280 Paper 29789704 Paper 29767638 Paper 29679048 Paper 29653926 Paper 29633705 Paper 29602632 Paper 29596840 Paper 29532235 Paper 29529007 Paper 29511889 Paper 29472416 Paper 29471684 Paper 29270534 Paper 29183737 Paper 29065913 Paper 29058155 Paper 29029629 Paper 28992097 Paper 28978534 Paper 28889816 Paper 28851704 Paper 28821332 Paper 28755073 Paper 28712521 Paper 28679593 Paper 28620062 Paper 28601936 Paper 28469399 Paper 28435306 Paper 28430754 Paper 28417544 Paper 28361601 Paper 28332475 Paper 28270931 Paper 28186904 Paper 28163310 Paper 28029393 Paper 27959707 Paper 27797887 Paper 27785626 Paper 27746155 Paper 27743042 Paper 27658322 Paper 27618162 Paper 27605163

Abstract

The Cincinnati Children's Hospital Medical Center Biomarker Core (Core C) with provide support for all aspects of biomarker research to the Pediatric Centers of Excellence in Nephrology. These services range from specimen handling, biofluid profiling and discovery, to assay development and biomarker validation, to commercialization. The overarching goal of Biomarker Core C is to provide an innovative service for the seamless discovery, translation, validation, and commercialization of novel biomarkers and therapeutic targets for human diseases, in collaboration with other cores. The Biomarker Core, founded by Prasad Devarajan, MD, and co-directed by Michael Bennett, PhD, is housed in the Division of Nephrology and Hypertension at Cincinnati Children's Research Foundation. Through collaborative and fee-for-service arrangements, the lab has grown into a wide-ranging service and research provider for clinicians and investigators across the globe. Over the past three years, we have performed well over 200,000 assays for AKI and CKD biomarkers for investigators worldwide. Dr. Bennett has a broad background in cell biology, molecular biology and biochemisty. He was recruited to join Dr. Devarajan's team 5 years ago to direct the Biomarker Core and supervise the research operations of the Nephrology Clinical Laboratory. The seamless connection to the CAP and CLIA certified clinical laboratory provides the Biomarker Core access to a diverse menu of advanced clinical assays on high throughput standardized clinical laboratory platforms. Several of the research projects in this application (Goldstein, Brunner, Basu, Jodele,) require the services of the Biomarker Core to fulfill their Aims. To serve the needs of this team of investigators, the Biomarker Core will focus on these two specific aims: (1) To provide high throughput Clinical Biofluid Profiling Services using SELDI-TOF (list investigators who will use this), and (2) To provide services pertaining to Biomarker measurement and validation (including Design of ELISA and Western Blots, Measurement of markers of AKI and CKD, as well as consultation for biomarker statistics and clinical trials design).

View original record on NIH RePORTER →