TREATMENT OF SCHIZOAFFECTIVE DISORDER USING MIFEPRISTONE

$0M01FY2001RRNIH

Stanford University, Stanford CA

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Abstract

This study uses the glucocorticoid-receptor antagonist RU486 (mifepristone) to treat patients with a diagnosis of schizoaffective disorder. It is hypothesized that these patients have elevated levels of cortisol which leads to a hyperdopaminergic state which in turn results in cognitive dysfunction and psychosis. There is evidence that high-dose mifepristone rapidly resolves these symptoms. Clinicals were begun in mid-1998 and continue. We have collected data on 2 patients with a diagnosis of schizoaffective disorder.

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