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VACCINATION WITH AUTOLOGOUS DENDRITIC CELLS WITH B CELL LYMPHOMA

$0M01FY2001RRNIH

Stanford University, Stanford CA

Investigators

Linked publications & trials

Abstract

This trial is designed to test the safety, immunogenicity, and clinical activity of autologous peripheral blood dendritic cells (DCs) pulsed with tumor-derived idiotype protein in patients with low-grade B-cell lymphoma. The long-term goal of this study is to develop a vaccine therapy which will induce a clinically effective immune response. The vaccine is produced on a custom basis from each patient's tumor cells and peripheral blood. In a pilot study, cellular immune responses and tumor regressions were observed.

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