PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF ACUTE TOLERANCE W/ CONTIN

$0M01FY2001RRNIH

Virginia Commonwealth University, Richmond VA

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Abstract

To determine the phamacokinetic/pharmacodynamic profile for an intravenous infusion of furosemide in healthy young and healthy elderly subjects without volume replacement. To develop a model that incorporates physiologic variables to account for observed pharmacodynamic differences in the above populations.

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