CHOLESTEROL METABOLISM IN PLASMA LIPOPROTEINS &LIVER: STUDIES IN TWO

$0M01FY2001RRNIH

Virginia Commonwealth University, Richmond VA

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Abstract

To identify in vivo kinetic abnormalities of hepatic intracellular cholesterol traffic in sitosterolemia and Niemann-Pick Disease type C. Three isotopic com-pounds will be used to trace the cholesterol in three distinct cellular sites (plasma membrane, lysosome, and newly synthesized ER membrane vesicles). Results will be quantitated by compartmental analysis and compared to normal subjects.

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