A PHASE II MULTICENTER TRIAL OF INTRATUMORAL/INTERSTITIAL THERAPY WITH HN-6600

$0M01FY2001RRNIH

Virginia Commonwealth University, Richmond VA

Investigators

Linked publications & trials

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Abstract

HN-66000 is a proprietary pharmaceutical formulation of mutant diphthieria toxin and human transferrin that is being developed as a potential treatment for malignant brain tumors. The results from Phase I trial sponsored by the NIH suggest that the drug produces tumor responses in patients with malignant brain tumors refractory to conventional therapy without severe neurologic or systemic toxicity. The encouraging results warrant an expanded evaluation in a phase II trail.

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