Posttranslational Modifications in Natural Product Biosynthesis

$266,504R01FY2013GMNIH

University Of Illinois At Urbana-Champaign, Urbana IL

Investigators

Linked publications & trials

Paper 38719200 Paper 38559119 Paper 37389248 Paper 36625436 Paper 36107785 Paper 36044589 Paper 36001880 Paper 35613706 Paper 35258967 Paper 34725492 Paper 34283964 Paper 32939523 Paper 32493223 Paper 32293871 Paper 31751505 Paper 31532570 Paper 31409709 Paper 31320540 Paper 31243957 Paper 31042373 Paper 30638446 Paper 30484123 Paper 30183279 Paper 30177849 Paper 30090246 Paper 29938020 Paper 29537838 Paper 29507389 Paper 28691075 Paper 28260651 Paper 27700071 Paper 27599269 Paper 27348535 Paper 27178086 Paper 27123925 Paper 27074593 Paper 27028884 Paper 26979951 Paper 26933734 Paper 26877024 Paper 26675417 Paper 26361061 Paper 26323613 Paper 26226635 Paper 26006047 Paper 25888176 Paper 25803126 Paper 25723375 Paper 25619528 Paper 25515891 Paper 25460269 Paper 25409537 Paper 25363770 Paper 25244001 Paper 25092299 Paper 24972336 Paper 24866416 Paper 24405370 Paper 24325644 Paper 24169799 Paper 24038659 Paper 23789944 Paper 23666908 Paper 23621626 Paper 23589847 Paper 23314913 Paper 23071302 Paper 23034674 Paper 23001385 Paper 22920239 Paper 22841713 Paper 22725258 Paper 22574919 Paper 22524291 Paper 22480178 Paper 22431611 Paper 22404629 Paper 22003874 Paper 21910430 Paper 21802007 Paper 21770392 Paper 21229987 Paper 21196935 Paper 21114289 Paper 21095156 Paper 21046030 Paper 20608676 Paper 20479271 Paper 20351769 Paper 20016494 Paper 19678697 Paper 19663480 Paper 19655738 Paper 19632472 Paper 19632471 Paper 19374997 Paper 19292452 Paper 19222036 Paper 19007184 Paper 18940665

Abstract

DESCRIPTION (provided by applicant): Lantibiotics are post-translationally modified peptide antibiotics. Nisin, its best known member, has been used for decades in the food industry without significant development of resistance. Other lantibiotics are under investigation or in clinical trials for the treatment of cystic fibrosis and asthma, the elimination of tooth-decay causing bacteria, and for the treatment of multi-drug resistant bacteria. In this grant application we seek to extend our past success towards the use of the biosynthetic machinery to make analogs and to better understand their mechanism of substrate recognition and catalysis. Our goals are: 1. Understand the enzymes involved in crosslink formation 2. Engineer efficient processes to manipulate the structures of posttranslationally modified peptide natural products 3. Investigate new posttranslationally modified peptide natural products.

View original record on NIH RePORTER →