PAROXETINE IN PLATELET REACTIVITY IN MAJOR DEPRESSION

$0M01FY2001RRNIH

Emory University, Atlanta GA

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Abstract

This study is an amendment to SPID 3250 to provide two more weeks of open-label treatment with paroxetine in combination with antiplatelet agents, aspirin and clopidegril if the patient was being treated with paroxetine during the double-blind portion of the study. The extra two weeks of treatment will further elucidate the mechanism whereby paroxetine diminishes activation of the GPIIb/IIIa receptor in patients with major depression.

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