REGULATION OF LEPTIN IN HUMANS

$0M01FY2001RRNIH

Washington University, Saint Louis MO

Investigators

Linked publications & trials

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Abstract

A total of 262 subjects will be enrolled in about 400 patient interventions and about 200 outpatient interventions over 5 years. Subjects will be randomized to treatment w various glucocorticoids/placebo alone or along w metabolic manipulations (caloric restriction/loading, lipolysis stimulation/ inhibition, etc.). The primary end points are leptin levels in plasma and gene expression in subcutaneous abdominal fat cells.

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