Histopathology

Cleveland Clinic Lerner Com-Cwru, Cleveland OH

Investigators

Linked publications & trials

Abstract

The Histopathology Core will provide integral support for all 3 projects. This core will centralize the pathology resources for all of the projects of the PPG. This will result in cost savings, increased quality control and maximal comparability between the results of the projects. Key functions of the Core include: 1) expert advise in immunohistological aspects of experimental design to optimize results; 2) uniform tissue processing; 3) tissue sectioning (frozen sections and paraffin-embedded sections); 4) histochemical and immunohistochemical staining of tissue sections; 5) pathological interpretation of tissue sections; 6) documentation of the pathology by high quality digital microscopic photography; 7) preparation of figures for manuscripts; 8) storage and retrieval of stained slides for each of the projects. In addition, this Core will be responsible for ordering, quality assurance and control studies of all antibodies and reagents for use in the pathology methods. New reagents will be developed and evaluated as requested by investigators in the 3 projects.