Combination of Nanofiber Scaffolds with Gradations in Fiber Organization and Mine

Marshall University, Huntington WV

Investigators

Linked publications, trials & patents

Abstract

DESCRIPTION (provided by applicant): This grant proposal entitled Combination of Nanofiber Scaffolds with Gradations in Fiber Organization and Mineral Content and Adipose-derived Stem Cells for Rotator Cuff Injury Repair addresses the challenge in engineering a tissue construct to repair rotator cuff injury. The research issues we will address in the current grant proposal are three-fold: 1) Developing novel nanofiber scaffolds that will recapitulate the native structure and composition of tendon-to-bone insertion site, 2) Regulating the behaviors of adipose- derived stem cells (ADSCs) including morphology, proliferation, migration, and differentiation using nanofiber scaffolds, and 3) Testing the efficacy of ADSCs seeded nanofiber scaffolds using a rat shoulder injury model. To address our objectives, we are taking advantage of a unique opportunity to combine expertise from two research groups at Marshall University to ensure high level of productivity during the proposed funding period. Dr. Xie's laboratory has extensive experience in fabrication of nanofiber scaffolds and examination of interaction between cells and nanofiber scaffolds including culture and differentiation of adult and embryonic stem cells. Dr. Shuler has extensive experience in the animal model and clinical treatment of rotator cuff injury. Both research groups have the necessary skills and technology required to immediately carry out the work proposed.