Stress-Lead Interactions and Child Development

$616,740R01FY2013ESNIH

Icahn School Of Medicine At Mount Sinai, New York NY

Investigators

Linked publications & trials

Paper 39674324 Paper 39536662 Paper 39358346 Paper 39293757 Paper 39232724 Paper 39117147 Paper 38885590 Paper 38796021 Paper 38759779 Paper 38660759 Paper 38443464 Paper 38410473 Paper 38365053 Paper 38354885 Paper 38343740 Paper 38343731 Paper 38309331 Paper 38278245 Paper 38260714 Paper 38260407 Paper 38176546 Paper 38128386 Paper 37973255 Paper 37942546 Paper 37884142 Paper 37442254 Paper 37426026 Paper 37293091 Paper 37286025 Paper 37214901 Paper 36777528 Paper 36634862 Paper 36554375 Paper 36422900 Paper 36416295 Paper 36396698 Paper 36310839 Paper 36304836 Paper 36252845 Paper 36128727 Paper 36088418 Paper 36040907 Paper 35797845 Paper 35597113 Paper 35429215 Paper 35286908 Paper 35108597 Paper 35101400 Paper 34935432 Paper 34893088 Paper 34875261 Paper 34848207 Paper 34814962 Paper 34793781 Paper 34563522 Paper 34537199 Paper 34534313 Paper 34506780 Paper 34478773 Paper 34478771 Paper 34444524 Paper 34438564 Paper 34354022 Paper 34246643 Paper 34246641 Paper 34152198 Paper 34141453 Paper 34051199 Paper 34017930 Paper 33965768 Paper 33788852 Paper 33678412 Paper 33652701 Paper 33635093 Paper 33582606 Paper 33414500 Paper 33395951 Paper 33354655 Paper 33324494 Paper 33233802 Paper 33223137 Paper 33159880 Paper 33125398 Paper 33068586 Paper 33036323 Paper 33000714 Paper 32950567 Paper 32897104 Paper 32599353 Paper 32371274 Paper 32337473 Paper 32140430 Paper 32099952 Paper 32004829 Paper 31944681 Paper 31936138 Paper 31926485 Paper 31891650 Paper 31881529 Paper 31857145

Abstract

DESCRIPTION (provided by applicant): Previous studies on lead have typically analyzed covariate markers of social stress as independent predictors of neurodevelopment, considering them potential confounders. There are biological reasons to believe that psychosocial stress potentiates the toxicity of lead. If so, then understanding this relationship may be the key to designing effective public health interventions designed to improve neurodevelopment in children. The ELEMENT cohort has created the infrastructure for such a study and is uniquely positioned to address these important neurotoxicological questions. In this competing renewal, we hypothesize that lead exposure and social stressors experienced jointly in pregnancy and infancy will have multiplicatively increased deleterious effects on neurodevelopment (i.e. environment X environment interactions). Based on work conducted by others in animals, this should result in selective impairments in memory (hippocampus) and fixed interval responses (nucleus accumbens) due to the established vulnerability of these structures to stress and lead. Our results thus far have established a consistent pattern of adverse effects to both lead and social stress, as well as disturbed salivary cortisol rhythms following high levels of stress. We also find multiplicative changes in cortisol rhythms when these exposures occur in the context of high lead exposure. Cortisol may thus represent a mechanistic link between lead and stress. We have already enrolled 1000 infants in Mexico City measuring stress and lead exposure longitudinally beginning in the 2nd trimester through age 2 years. To date, we have measured only infant development via Bayley Scales. In this renewal we propose to measure more detailed neurophenotypes as the children age (behavior, cognition, memory) as well as tests specific to hippocampal and nucleus accumbens function. Social and educational interventions, if targeted properly, could be effective treatments. This research will identify those interventions.

View original record on NIH RePORTER →