Trauma-Related Olfactory Cues in Posttraumatic Stress Disorder

Medical University Of South Carolina, Charleston SC

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Abstract

DESCRIPTION (provided by applicant): The proposed career development plan is designed for the candidate to acquire the knowledge and skills necessary to develop a high quality, independent research program in the areas of olfaction and posttraumatic stress disorder (PTSD).The candidate proposes career development activites such as graduate coursework, didactics, and applied experience that is focused on the central olfactory system, anxiety and PTSD, functional neuroimaging (fMRI), psychophysiology, statistics, and ethical conduct in research. Although odors have been described as more closely linked to memory, and emotional memories specifically, than stimuli from any other sensory modality, and odors are commonly associated with traumatic events, the role of the central olfactory system (e.g. olfactory triggers) has yet to be systematically studied in PTSD. The proposed research plan, designed to address the gap in our understanding of the brain mechanisms involved in PTSD, includes (a) to assess odor threshold, odor identification, and odor memory in combat veterans with and without PTSD, (b) to assess the behavioral and physiological profiles of odor-induced anxiety and odor-related trauma in combat veterans with and without PTSD, and (c) to utilize a validated olfactory fMRI protocol to compare neural activation in the central olfactory and fear pathways after exposure to trauma-related and control odors in combat veterans with and without PTSD. The information acquired from the planned olfactory experiments could have implications for personalized medicine, potentially identifying PTSD patients that require the use of odors to achieve a complete therapeutic response to behavioral exposure therapy.