Compact x-ray nanoscopy

National Heart, Lung, And Blood Institute

Investigators

Linked publications & trials

Abstract

To realize nano scale x-ray imaging on a benchtop scale without highly specialized and costly x-ray optical componenets, we are developing an amplified photoresist film that is sensitive to x-ray and electron beam radiation, and can support nanometer scale features. These features are read accurately quantified by a compact atomic force microscopy. We have achieved initial success in a gold amplified E-beam resist system and obtained radiographs of x-ray gratings at 50 nm resolution. Concurrently, we are developing a new way to observe the interaction of x-ray with biological samples by imaging the reactive oxygen species produced by the x-ray beam. This approach is aimed to improve the contrast and specificity of nanometer scale x-ray microscopy of biological samples.