Genome-wide mapping of histone modifications

$1,509,004ZIAFY2012HLNIH

National Heart, Lung, And Blood Institute

Investigators

Linked publications & trials

Paper 39007366 Paper 38866970 Paper 38811575 Paper 38614090 Paper 38280375 Paper 37540600 Paper 37177993 Paper 37040761 Paper 36996023 Paper 36807066 Paper 36735533 Paper 35804086 Paper 35748872 Paper 34928392 Paper 33995409 Paper 33853847 Paper 33693880 Paper 33244170 Paper 32759226 Paper 32561719 Paper 32265226 Paper 32181817 Paper 32086528 Paper 32019910 Paper 31836865 Paper 30923384 Paper 30554876 Paper 30470739 Paper 30401810 Paper 30258225 Paper 30254051 Paper 30150754 Paper 29973406 Paper 29681542 Paper 29466755 Paper 29323272 Paper 29043624 Paper 29022941 Paper 28986433 Paper 28945250 Paper 28862252 Paper 28446439 Paper 28434938 Paper 28253434 Paper 28250416 Paper 27941795 Paper 27601472 Paper 27346580 Paper 27259149 Paper 27058666 Paper 26846280 Paper 26814149 Paper 26605532 Paper 26471251 Paper 26107953 Paper 26086782 Paper 25960866 Paper 25896894 Paper 25840414 Paper 25598842 Paper 25303531 Paper 25269644 Paper 25079229 Paper 25056547 Paper 24922058 Paper 24916307 Paper 24829942 Paper 24743998 Paper 24743988 Paper 24675960 Paper 24495580 Paper 24486021 Paper 24452266 Paper 24288132 Paper 24176123 Paper 24067902 Paper 23950721 Paper 23940283 Paper 23938295 Paper 23823717 Paper 23779104 Paper 23754954 Paper 23716702 Paper 23698369 Paper 23610375 Paper 23538681 Paper 23510235 Paper 23260488 Paper 23135404 Paper 23101626 Paper 23072359 Paper 23041064 Paper 22929775 Paper 22897906 Paper 22848633 Paper 22570707 Paper 22511886 Paper 22431584 Paper 22429979 Paper 22310283

Abstract

The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. No principle yet unifies Myc action due partly to an incomplete inventory and functional accounting of Mycs targets. To observe Myc- target expression and function in with Myc levels in a temporally and physiologically regulated system, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II and chromatin modifications were compared during lymphocyte activation and in ES cells. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off specifier of gene activity, but is a non-linear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.

View original record on NIH RePORTER →