Development of Monoclonal Antibodies to Types C, D, F and G Botulinum Toxins

National Institute Of Allergy And Infectious Diseases

Investigators

Abstract

Clostridium botulinum neurotoxins are known to be among the most potent and dangerous biological agents, because exposure to them can cause a life threatening paralytic disease syndrome. This IAA will support the development of monoclonal antibodies for neutralization of botulinum neurotoxin serotypes C, D, F and G, as well as support in vivo studies to characterize the potency of these antibodies.