FUNCTIONAL ORGANIZATION OF NEURAL CIRCUITS IN THE MOUSE ACCESSORY OLFACTORY BULB

Ut Southwestern Medical Center, Dallas TX

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Abstract

PROJECT SUMMARY/ABSTRACT The overall goal of this research and training plan is to gain better understanding of the organization and function of the mouse accessory olfactory system (AOS). The AOS is a compact neural pathway that communicates directly with brain regions that govern so-called intrinsic social and reproductive behaviors. By increasing knowledge about sensory processing in the mouse AOS, this project will shed light on principles of mammalian olfaction, and will improve our understanding of links between sensation and behavior. The investigator, Dr. Julian Meeks, will gain up to two years of advanced postdoctoral training in the design and implementation of planar illumination microscopy and transgenic mice in support of an innovative approach using live neuronal calcium imaging to study inhibitory interneurons in the mouse accessory olfactory bulb. Two sponsors for this training were chosen, Dr. Timothy Holy and Dr. Daniel Kerschensteiner, that have strong experience in the fields of optical design and transgenic mouse production, respectively. Several hypotheses will be tested during the mentored and independent phases of this award. One main hypothesis links sensory receptive fields to axonal projection patterns in the brain. Testing several other hypotheses will identify specific sensory processing roles for the various interneuron populations in the accessory olfactory bulb. Testing these hypotheses will establish principles of mammalian social odor processing, and will help us to understand the functions that inhibitory neurons provide for sensory neural circuits. Through this research and mentored training plan, Dr. Meeks will produce valuable new data on AOS sensory processing, and will establish new experimental tools and approaches that will form a foundation for a career as an independent scientist.