Pilot 5 - Developmental Exposure Alcohol Research Center

$8,202P50FY2012AANIH

State University Of Ny,Binghamton, Binghamton NY

Investigators

Linked publications & trials

Paper 39442640 Paper 39304172 Paper 39288866 Paper 39148897 Paper 39043342 Paper 38906480 Paper 38897258 Paper 38838083 Paper 38746266 Paper 38332987 Paper 38268931 Paper 38162404 Paper 38152067 Paper 38131243 Paper 37962155 Paper 37590138 Paper 37566070 Paper 37148274 Paper 37137354 Paper 36941800 Paper 36862971 Paper 36577734 Paper 36155778 Paper 35851872 Paper 35706690 Paper 35643257 Paper 35478009 Paper 35447157 Paper 35364101 Paper 35341791 Paper 35245677 Paper 34801170 Paper 34801169 Paper 34624301 Paper 34450212 Paper 34272687 Paper 34246729 Paper 34097948 Paper 33977545 Paper 33741404 Paper 33718895 Paper 33690917 Paper 33619752 Paper 33458889 Paper 33301050 Paper 33159929 Paper 33094531 Paper 33067870 Paper 32998090 Paper 32950559 Paper 32789537 Paper 32717830 Paper 32535179 Paper 32505093 Paper 32068904 Paper 32056231 Paper 32012419 Paper 31995285 Paper 31855302 Paper 31733669 Paper 31733665 Paper 31733663 Paper 31707090 Paper 31675629 Paper 31634523 Paper 31493315 Paper 31446016 Paper 31096263 Paper 30926450 Paper 30807864 Paper 30797833 Paper 30797832 Paper 30742967 Paper 30674037 Paper 30667526 Paper 30597200 Paper 30589435 Paper 30472309 Paper 30450378 Paper 30450375 Paper 30322483 Paper 30171932 Paper 30144202 Paper 29682808 Paper 29571047 Paper 29467469 Paper 29458194 Paper 29442358 Paper 29095430 Paper 29033803 Paper 28803453 Paper 28566946 Paper 28522965 Paper 28319836 Paper 28257889 Paper 28201924 Paper 27871862 Paper 27524639 Paper 27497719 Paper 27484868

Abstract

Ethanol neurotoxicity affects neurotransmitter release. Experiments will be carried to test the hypothesis that ethanol exposure results in structural and biochemical changes in presynaptic terminals. First, a transgenic mouse that expresses yellow fluorescent protein (YFP) in a subset of cerebellar mossy fiber terminals will be used to determine whether ethanol treatment affects the size of the mossy fiber terminals. Second, the effect of ethanol on presynaptic protein SNAP-25 will be determined. These experiments will provide novel insights on how ethanol affects cerebellar circuitry at presynaptic terminals.

View original record on NIH RePORTER →