Development and availability of the Collaborative Cross (CC) panel of recombinan

$218,896U54FY2012AINIH

Univ Of North Carolina Chapel Hill, Chapel Hill NC

Investigators

Linked publications & trials

Paper 34060904 Paper 33621239 Paper 32799623 Paper 32708789 Paper 31138630 Paper 30471923 Paper 30393776 Paper 30341219 Paper 29789360 Paper 29324290 Paper 29211244 Paper 29138302 Paper 28986840 Paper 28986837 Paper 28986834 Paper 28986833 Paper 28986832 Paper 28652311 Paper 28646220 Paper 28248203 Paper 27746192 Paper 27622947 Paper 27348054 Paper 27232126 Paper 27222471 Paper 26772634 Paper 26682988 Paper 26631631 Paper 26512092 Paper 26463167 Paper 26459652 Paper 26366337 Paper 26301593 Paper 26192357 Paper 26180833 Paper 26159721 Paper 26138979 Paper 26060274 Paper 26032420 Paper 26032161 Paper 26029367 Paper 25992778 Paper 25964458 Paper 25939507 Paper 25924766 Paper 25918406 Paper 25803288 Paper 25781467 Paper 25711908 Paper 25706132 Paper 25698059 Paper 25691593 Paper 25665078 Paper 25611317 Paper 25542773 Paper 25512308 Paper 25275316 Paper 25250027 Paper 25220212 Paper 25217165 Paper 25142598 Paper 25136102 Paper 25100837 Paper 25078919 Paper 25024199 Paper 24981333 Paper 24952767 Paper 24939850 Paper 24928986 Paper 24928049 Paper 24918450 Paper 24895309 Paper 24889229 Paper 24837506 Paper 24807715 Paper 24772391 Paper 24760885 Paper 24739760 Paper 24733050 Paper 24715728 Paper 24712471 Paper 24696344 Paper 24696329 Paper 24686053 Paper 24675902 Paper 24667706 Paper 24599590 Paper 24583361 Paper 24520064 Paper 24510290 Paper 24487921 Paper 24478083 Paper 24449562 Paper 24421336 Paper 24395821 Paper 24385585 Paper 24371059 Paper 24348241 Paper 24344237 Paper 24336226

Abstract

The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight founder mouse strains. We have recently genotyped 450 CC lines to provide the first accurate description of the genetic architecture of the CC population. We are now focused on making the largest number of lines accessible to the researchers as soon as possible through genotyping and re-derivation of CC lines nearing the thresholds for distribution (>90% inbred) and completion (>98% inbred). There are currently 27 CC lines in the distribution list and we expect to have a minimum of 50 CC lines by the end of 2012 and 100 CC lines by 2103. The CC is a Genetic Reference Population and, therefore, the number of lines available has a direct impact in the power of detecting loci with small to moderate effects and on the ability to select lines that are uniquely suited to specific research projects.

View original record on NIH RePORTER →