COBRE for Skeletal Health and Repair

$2,192,326P20FY2012GMNIH

Rhode Island Hospital, Providence RI

Investigators

Linked publications & trials

Paper 33241856 Paper 32897799 Paper 32650430 Paper 31631704 Paper 31341031 Paper 31287165 Paper 31287025 Paper 31206541 Paper 31174845 Paper 31168963 Paper 31125133 Paper 30822327 Paper 30729978 Paper 30414786 Paper 30397184 Paper 30392774 Paper 30277839 Paper 30180091 Paper 30157934 Paper 30019965 Paper 29962255 Paper 29940371 Paper 29755599 Paper 29729351 Paper 29728632 Paper 29671154 Paper 29644115 Paper 29575548 Paper 29440889 Paper 29438978 Paper 29358076 Paper 29316362 Paper 29284451 Paper 29231776 Paper 29227559 Paper 29149841 Paper 29146510 Paper 29085371 Paper 29016733 Paper 28983104 Paper 28975657 Paper 28975136 Paper 28945358 Paper 28875154 Paper 28836462 Paper 28790177 Paper 28743292 Paper 28718315 Paper 28711411 Paper 28710904 Paper 28709737 Paper 28608618 Paper 28604608 Paper 28579418 Paper 28511594 Paper 28471397 Paper 28447179 Paper 28436754 Paper 28359570 Paper 28306503 Paper 28222626 Paper 28160934 Paper 28129516 Paper 27935612 Paper 27763799 Paper 27594677 Paper 27545621 Paper 27511596 Paper 27464254 Paper 27411036 Paper 27270603 Paper 27253997 Paper 27159308 Paper 27149270 Paper 27143978 Paper 27142253 Paper 27106144 Paper 27069948 Paper 27023516 Paper 27019614 Paper 26975998 Paper 26861287 Paper 26792705 Paper 26752378 Paper 26629963 Paper 26457483 Paper 26455390 Paper 26339112 Paper 26285913 Paper 26075411 Paper 26046079 Paper 26013170 Paper 25964211 Paper 25941135 Paper 25939612 Paper 25913243 Paper 25907550 Paper 25889158 Paper 25854697 Paper 25818732

Abstract

DESCRIPTION (provided by applicant): The long-term goal of the Center of Biomedical Research Excellence (COBRE) is to develop a multidisciplinary translational research center focusing on discovering cartilage and joint health and disease mechanisms and developing repair strategy. During the Phase I of COBRE, great progress has been made in mentoring junior investigators into leaders of R01 grant funded research programs. The main objective of the Phase II COBRE is to sustain the success by recruiting more promising junior investigators into the COBRE research programs thereby further expanding and enhancing the base of skeletal research in Rhode Island Hospital and Brown University. The new research projects encompass clinical, biological, and engineering research fields. Project 1 analyzes how mechanical loading affects long bone growth during skeletal development. Project 2 examine how joint cartilage degenerates in adult joint diseases. Project 3 develops novel strategies of harvesting stem cells from fat tissues to repair bone. The investigators and mentors are selected from three departments in Rhode Island Hospital/The Alpert Medical School of Brown University (Orthopaedics, Medicine, and Molecular Pharmacology, Physiology, and Biotechnology). The junior investigators include a biologist, a bioengineer, and a clinician/scientist. The mentors also include biologists, engineers, and clinician/scientists. Eachmentor is a Principal Investigator of multiple federal grants including NIH R01. They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by sustaining and developing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multidisciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.

View original record on NIH RePORTER →