Explosive Evolution Under Stress: The Driving Forces of Cancer Dynamics (Main)

$2,775,982U54FY2012CANIH

Princeton University, Princeton NJ

Investigators

Linked publications & trials

Paper 39071340 Paper 38385626 Paper 37758847 Paper 37700000 Paper 37644281 Paper 37326720 Paper 37172462 Paper 36598661 Paper 36372998 Paper 35972622 Paper 35962062 Paper 35906318 Paper 35810282 Paper 35563113 Paper 35225262 Paper 34793840 Paper 34581907 Paper 34346466 Paper 34331598 Paper 34089393 Paper 33991583 Paper 33949714 Paper 33760984 Paper 33596381 Paper 33504594 Paper 33279670 Paper 33276091 Paper 32952609 Paper 32920666 Paper 32587951 Paper 32535731 Paper 32524295 Paper 32234827 Paper 32172294 Paper 32115854 Paper 31980749 Paper 31376205 Paper 31088471 Paper 30479377 Paper 29755698 Paper 29666828 Paper 29651130 Paper 29623956 Paper 29527324 Paper 29432873 Paper 29339080 Paper 29285777 Paper 28912577 Paper 28651527 Paper 28348171 Paper 28256233 Paper 28058627 Paper 27982511 Paper 27819283 Paper 27796957 Paper 27739046 Paper 27705752 Paper 27663743 Paper 27659015 Paper 27634877 Paper 27517159 Paper 27401672 Paper 27213557 Paper 27172799 Paper 27168390 Paper 27151975 Paper 27028863 Paper 27008704 Paper 26900985 Paper 26853861 Paper 26472542 Paper 26458994 Paper 26400105 Paper 26317796 Paper 26240372 Paper 26165921 Paper 26153702 Paper 26029631 Paper 26027638 Paper 26024203 Paper 25944618 Paper 25940699 Paper 25895024 Paper 25855487 Paper 25850653 Paper 25760966 Paper 25752274 Paper 25640606 Paper 25619322 Paper 25492931 Paper 25353522 Paper 25344858 Paper 25339441 Paper 25329892 Paper 25327565 Paper 25172842 Paper 25074613 Paper 25014042 Paper 24884963 Paper 24700698

Abstract

The re-emergence of resistant cancer cells after initial therapy is one of the great unsolved, and deadly, problems in oncology, and a fundamental problem of evolution under stress. This project is aimed at understanding, from general principles of physics, ecology, and biology, why recurrence of resistant cancer cells seems to be a universal phenomenon in cancer. We believe that evolution in small, stressed habitats is the key to the rapid and inevitable re-emergence of resistance. The physical technology that drives this Project uses microfabrication of tiny, stressed habitats to test these Ideas. Modern techniques of physical probes, genomics, proteomics and nanotechnology will allow us to analyze the evolutionary path of these emergent resistant cells.

View original record on NIH RePORTER →