Cancer and Gene Regulation by Non-coding RNAs

$818,083P01FY2012CANIH

Massachusetts Institute Of Technology, Cambridge MA

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Abstract

PROJECT SUMMARY (See Instructions): MicroRNAs are predicted to regulate a majority of genes in human cells and both overexpression and loss of expression of some miRNAs are correlated with malignant phenotypes in different cancer cells. A decrease in miRNA activity is most commonly observed and may be important for the plasticity of tumor cells to undergo transitions between differentiation states and to grow in different niches. In Aim 1 of this Project we plan to investigate

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