HORMONAL CONTROL OF HUMAN TESTICULAR FUNCTION

$166,470U54FY2000HDNIH

University Of Washington, Seattle WA

Investigators

Linked publications, trials & patents

Paper 24715688 Paper 23776628 Paper 22893725 Paper 22396414 Paper 22396413 Paper 22341266 Paper 21933870 Paper 21914775 Paper 21363930 Paper 21289266 Paper 21045176 Paper 20827265 Paper 20732875 Paper 20525909 Paper 20484472 Paper 20181609 Paper 20152817 Paper 19861584 Paper 19779211 Paper 19776272 Paper 19770291 Paper 19755669 Paper 19686750 Paper 19666516 Paper 19625529 Paper 19479252 Paper 19443569 Paper 19321788 Paper 19074277 Paper 18775887 Paper 18772143 Paper 18644415 Paper 18436704 Paper 18046048 Paper 18032697 Paper 17988212 Paper 17978050 Paper 17950270 Paper 17904653 Paper 17898535 Paper 17761644 Paper 17699664 Paper 17494097 Paper 17462643 Paper 17314233 Paper 17303493 Paper 17289929 Paper 17244764 Paper 17204549 Paper 16940442 Paper 16932251 Paper 16882745 Paper 16842770 Paper 16793876 Paper 16762492 Paper 16728532 Paper 16503925 Paper 16461287 Paper 16400081 Paper 16373418 Paper 16352669 Paper 16339030 Paper 16291925 Paper 16113587 Paper 16036917 Paper 15919741 Paper 15867009 Paper 15831567 Paper 15713727 Paper 15713724 Paper 15665556 Paper 15611571 Paper 15579744 Paper 15477366 Paper 15371594 Paper 15340140 Paper 15249737 Paper 15223051 Paper 15217982 Paper 15070942 Paper 14962070 Paper 14657352 Paper 14644020 Paper 12960003 Paper 12954663 Paper 12835474 Paper 12736156 Paper 12639894 Paper 12629101 Paper 12588848 Paper 12586757 Paper 12359505 Paper 12107227 Paper 12004056 Paper 11875122 Paper 11861493 Paper 11713207 Trial NCT01215292 Trial NCT00839319 Patent 7138389

Abstract

The general objective of this work is to define carefully the endocrine milieu that is required to maintain normal testicular function in men. In particular, we are concerned with the gonadotropin and steroid environment necessary to stimulate human spermatogenesis. We will be experimentally manipulating the hormonal environment of the testis in normal men and determining the resultant effects on spermatogenesis. More specifically, the objectives of this work are to answer four questions: 1. Can the combination of a gonadotropin-releasing hormone (GnRH) antagonist plus testosterone (T) suppress gonadotropin secretion and thereby spermatogenesis more completely that can T alone? 2. Is the conversion of T to dihydrotestosterone (DHT) i.e. 5alpha reduction, important in the stimulation of human spermatogenesis? 3. Is the conversion of T to estradiol (E2), i.e. aromatization, important in the control of human sperm production? 4. What is the effect of supraphysiologic follicle-stimulating hormone (FSH) stimulation on human testicular function? This work will make use of new compounds, such as a GnRH antagonist and a 5alpha reductase inhibitor for exploring the normal physiologic control systems of human testicular function. Our studies are directly relevant to the development of safe, effective, reversible methods of male contraception and to the treatment of men with disorders of spermatogenesis.

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