Genetic analysis of p53 stability and activity

$318,795R01FY2012CANIH

University Of California, San Diego, La Jolla CA

Investigators

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Paper 24675459 Paper 24038750 Paper 23770853 Paper 22824795 Paper 22311782 Paper 21050134 Paper 20818388 Paper 19881536 Paper 19767771 Paper 18223686 Paper 17581277 Paper 17172844 Paper 16943427 Paper 16757976 Paper 15964796 Paper 15619621 Paper 12909629

Abstract

important and sometimes surprising insights into the complex regulation of p53. With these initial successes, I propose to continue to employ mouse genetics to investigate the roles of various phosphorylation and acetylation events in regulating p53 activity, and more importantly, in p53-dependent tumor suppression and aging in vivo. Project Description Page 6

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