BRAIN ACTIVATION FOLLOWING FFT IN YOUTH AT RISK FOR BIPOLAR DISORDER

$19,531P41FY2011RRNIH

Stanford University, Stanford CA

Investigators

Linked publications, trials & patents

Paper 36935627 Paper 35864992 Paper 32783339 Paper 32329076 Paper 31722599 Paper 31277060 Paper 30637847 Paper 28792653 Paper 28722314 Paper 28450978 Paper 28137627 Paper 27726251 Paper 27678106 Paper 27282860 Paper 27116907 Paper 26970093 Paper 26923108 Paper 26786745 Paper 26778549 Paper 26774615 Paper 26677408 Paper 26315797 Paper 26026643 Paper 25983363 Paper 25982242 Paper 25970596 Paper 25923677 Paper 25426935 Paper 25400102 Paper 25338633 Paper 25278065 Paper 25193002 Paper 25155435 Paper 25107618 Paper 24907854 Paper 24715414 Paper 24549830 Paper 24512800 Paper 24493404 Paper 24419985 Paper 24324530 Paper 24321559 Paper 24248734 Paper 24227703 Paper 24224182 Paper 24166577 Paper 24089369 Paper 23821305 Paper 23796090 Paper 23661904 Paper 23649942 Paper 23622097 Paper 23617511 Paper 23559437 Paper 23553967 Patent 9170312 Patent 8638096 Patent 8587311 Patent 8538115 Patent 8508225 Patent 8473536 Patent 8432166 Patent 7966053 Patent 7952353 Patent 7928729 Patent 7924002 Patent 7821263 Patent 7795868 Patent 7777486 Patent 7709266 Patent 7683618 Patent 7602183 Patent 7592807 Patent 7592806 Patent 7535222 Patent 7439739 Patent 7368910 Patent 7349729 Patent 7348776 Patent 7298144 Patent 7202662 Patent 7176683 Patent 7132828 Patent 7096056 Patent 6976953 Patent 6975895 Patent 6969991 Patent 6856134 Patent 6853191 Patent 6812700 Patent 6810110 Patent 6806709 Patent 6784664 Patent 6529002 Patent 6463315 Patent 6445181 Patent 6353752 Patent 6324240 Patent 6268728 Patent 6144873

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To investigate changes in brain activation associated with family focused treatment (FFT) in adolescents at high risk for developing bipolar disorder. Background: Previous studies have found that FFT is effective in stabilizing symptoms of mania and depression in adolescent patients. This treatment may also be associated with changes in the function of brain regions associated with emotional responses. Methods: Ten subjects with a family history of bipolar disorder and current subsyndromal symptoms completed scans at baseline and after 12 weeks of treatment (either treatment as usual or FFT). Functional magnetic resonance imaging scans were acquired using a spiral pulse sequence at 3T, while subjects viewed fearful and neutral faces. Whole brain data were processed in SPM5. Clusters of activation that changed significantly from baseline to follow-up were identified using a repeated measures ANOVA, and a dual threshold of p=.01, extent = 80. Mean activation in clusters that fell in a priori hypothesized regions was extracted. Due to the small sample size, all subjects were included in a single group, regardless of treatment condition. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

View original record on NIH RePORTER →