STRUCTURAL CHARACTERIZATION OF RNAP

$32,133P41FY2011RRNIH

Scripps Research Institute, The, La Jolla CA

Investigators

Linked publications, trials & patents

Paper 30471922 Paper 29867235 Paper 29512653 Paper 29460780 Paper 29258816 Paper 29039189 Paper 28724762 Paper 28223502 Paper 27288865 Paper 26792749 Paper 26634441 Paper 26404402 Paper 26301600 Paper 25807248 Paper 25569572 Paper 25316790 Paper 25271319 Paper 25259921 Paper 24673644 Paper 24503852 Paper 24361271 Paper 24335589 Paper 24288331 Paper 24189638 Paper 24161732 Paper 24145402 Paper 24068931 Paper 24055317 Paper 24027321 Paper 23999429 Paper 23824824 Paper 23824817 Paper 23708606 Paper 23658524 Paper 23520050 Paper 23449219 Paper 23442862 Paper 23431160 Paper 23426631 Paper 23334578 Paper 23319619 Paper 23240979 Paper 23223955 Paper 23217681 Paper 23180774 Paper 23179635 Paper 23143292 Paper 23132068 Paper 23132067 Paper 23022349 Paper 22982990 Paper 22896619 Paper 22878502 Paper 22840768 Paper 22830650 Paper 22771211 Paper 22748764 Paper 22727814 Paper 22645128 Paper 22569522 Paper 22509261 Paper 22464326 Paper 22445172 Paper 22426548 Paper 22405008 Paper 22366277 Paper 22308316 Paper 22308040 Paper 22245547 Paper 22237024 Paper 22225728 Paper 22160671 Paper 22113616 Paper 22100448 Paper 22072970 Paper 21998254 Paper 21964395 Paper 21962517 Paper 21933715 Paper 21781960 Paper 21632760 Paper 21617764 Paper 21506171 Paper 21504103 Paper 21454662 Paper 21439834 Paper 21344547 Paper 21325274 Paper 21187419 Paper 21182964 Paper 21134637 Paper 21130884 Paper 21030658 Paper 20957184 Paper 20947016 Paper 20888970 Paper 20888480 Patent 9738688 Patent 9702795 Patent 9594008

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The segmented, single-stranded RNA genome of the Influenza A Virus is packed by a nucleoprotein and a polymerase into Ribonucleoprotein complexes (RNPs), forming an antiparallel helix. The RNA is encapsidated by multiple nucleoproteins (~56kDa) and a trimeric polymerase is associated to the complex Despite the fundamental importance of RNPs for both viral replication, as well as the formation of infectious virion, its native structure remains unknown. The inherent flexibility of these complexes poses significant difficulties for three-dimensional structure determination.

View original record on NIH RePORTER →