STRUCTURE OF MCM21 PROTEIN COMPLEX

$10,975P41FY2011RRNIH

Cornell University, Ithaca NY

Investigators

Linked publications, trials & patents

Paper 38508190 Paper 33131423 Paper 32748788 Paper 32581365 Paper 32389689 Paper 30559425 Paper 30289389 Paper 29946027 Paper 28338692 Paper 28045370 Paper 27936128 Paper 27905149 Paper 27463675 Paper 26988700 Paper 26959646 Paper 26745345 Paper 26729507 Paper 26715336 Paper 26707939 Paper 26701219 Paper 26689263 Paper 26644568 Paper 26508639 Paper 26481813 Paper 26472759 Paper 26459562 Paper 26387779 Paper 26349032 Paper 26278175 Paper 26172141 Paper 26130467 Paper 25970265 Paper 25901326 Paper 25831534 Paper 25794619 Paper 25752492 Paper 25728769 Paper 25713376 Paper 25553844 Paper 25484204 Paper 25422158 Paper 25414009 Paper 25372812 Paper 25352689 Paper 25313043 Paper 25231992 Paper 25198768 Paper 25184411 Paper 25136110 Paper 25136092 Paper 25128388 Paper 25102080 Paper 25079952 Paper 25043052 Paper 24948331 Paper 24939935 Paper 24898247 Paper 24820088 Paper 24727379 Paper 24717845 Paper 24692304 Paper 24661065 Paper 24646888 Paper 24599961 Paper 24531000 Paper 24523505 Paper 24523405 Paper 24459150 Paper 24416224 Paper 24362703 Paper 24316823 Paper 24316736 Paper 24257752 Paper 24248594 Paper 24218560 Paper 24185281 Paper 24152548 Paper 24136005 Paper 24130488 Paper 24121512 Paper 24106986 Paper 24099674 Paper 24095061 Paper 24056041 Paper 24048029 Paper 24039739 Paper 24030827 Paper 23999292 Paper 23989139 Paper 23980151 Paper 23937054 Paper 23936628 Paper 23919482 Paper 23891289 Paper 23879525 Paper 23861496 Paper 23808589 Paper 23795296 Paper 23781103 Paper 23713611

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal is to determine the structures of components of the budding-yeast kinetochore, with a focus for this subproject on the proteins that link the inner kinetochore with proteins that make direct contact with mitotic spindle microtubules. During 2010, we studied the so-called COMA complex, a heterotetramer of Ctf19, Ome1, Mcm21, and Akp1. Ctf19 and Mcm21 form a stable heterodimeric subcomplex. We collected data to about 4 [unreadable] resolution from crystals of this heterodimer and determined an approximate structure, now being adjusted and refined with better data.

View original record on NIH RePORTER →