REQUEST FOR SUPPORT OF A TEACHING POSTDOCTORAL FELLOW

$63,877P20FY2011RRNIH

University Of Louisville, Louisville KY

Investigators

Linked publications & trials

Paper 39094954 Paper 36194009 Paper 34890772 Paper 31687925 Paper 30931350 Paper 29614295 Paper 29497912 Paper 29382671 Paper 29319823 Paper 29197979 Paper 27277141 Paper 27264359 Paper 27081652 Paper 27076424 Paper 27010837 Paper 26981369 Paper 26762836 Paper 26713731 Paper 26697387 Paper 26583908 Paper 26542393 Paper 26515323 Paper 26279602 Paper 26256519 Paper 26107351 Paper 25999268 Paper 25875294 Paper 25681180 Paper 25632406 Paper 25483336 Paper 25303335 Paper 25293549 Paper 25210480 Paper 25077036 Paper 25040590 Paper 24863475 Paper 24808906 Paper 24782501 Paper 24745005 Paper 24709747 Paper 24641478 Paper 24625056 Paper 24569806 Paper 24406899 Paper 24404440 Paper 24361506 Paper 24048286 Paper 24035030 Paper 23995634 Paper 23922931 Paper 23893078 Paper 23850071 Paper 23826173 Paper 23817991 Paper 23750695 Paper 23747862 Paper 23744053 Paper 23742275 Paper 23667718 Paper 23643898 Paper 23533589 Paper 23468653 Paper 23461570 Paper 23384094 Paper 23316162 Paper 23285269 Paper 22971005 Paper 22967011 Paper 22935098 Paper 22803786 Paper 22724427 Paper 22720090 Paper 22719926 Paper 22697494 Paper 22649077 Paper 22444875 Paper 22373349 Paper 22368389 Paper 22258284 Paper 22140580 Paper 22119580 Paper 22117008 Paper 22084302 Paper 22045191 Paper 22023670 Paper 22023227 Paper 21999392 Paper 21981824 Paper 21909303 Paper 21888654 Paper 21848957 Paper 21840976 Paper 21840085 Paper 21829638 Paper 21827812 Paper 21824971 Paper 21789473 Paper 21783437 Paper 21731731 Paper 21720950

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Inhibitors of the enzyme sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) are valuable research tools for the study of the enzyme's role in physiological processes and they also have the potential of being developed into new anti-cancer agents. A series of 2,5-disubstitued hydroquinones will be synthesized and their ability to inhibit SERCA will be assessed in bioassays. Based on the results, computational techniques such as structure-activity relationship modeling and ligand docking will be used to develop models capable of predicting the activities of yet untested, hydroquinone-based compounds. With the aid of these models, compound libraries will be screened virtually for novel SERCA inhibitors that then will be obtained and tested in bioassays.

View original record on NIH RePORTER →