Antibacterial Host Defense

National Institute Of Allergy And Infectious Diseases

Investigators

Linked publications & trials

Abstract

The purpose of the project is to find out how microbial molecules, such as bacterial lipopolysaccharides, induce the accumulation of triglycerides (i.e., fat droplets) in macrophages. This process is important for the pathogenesis of the foamy macrophages that are found at sites of infection (especially within granulomas) and in arterial walls (where macrophages contribute substantially to atherosclerosis). This project is still very young. We have promising data but no publications at this point.