Structures and Activities of Prions and Prion Proteins

$721,506ZIAFY2011AINIH

National Institute Of Allergy And Infectious Diseases

Investigators

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Paper 38392876 Paper 35831291 Paper 35771767 Paper 35752366 Paper 30646817 Paper 28910420 Paper 28835493 Paper 28704563 Paper 28431576 Paper 28091514 Paper 27880767 Paper 27685252 Paper 26937029 Paper 26246570 Paper 26175152 Paper 25416779 Paper 25028516 Paper 23808331 Paper 22222213 Paper 21593729 Paper 21558432 Paper 21539311 Paper 21441913 Paper 20304915 Paper 19596861 Paper 19297504 Paper 19231987 Paper 18487456 Paper 18394757 Paper 18368623 Paper 18309304 Paper 17925394 Paper 17709470 Paper 17643109 Paper 17287284 Paper 17176078 Paper 17051207 Paper 17046661 Paper 17046649 Paper 16980300 Paper 16873242 Paper 16866364 Paper 16495266 Paper 16474119 Paper 16379006 Paper 16378962 Paper 15933194 Paper 15917460 Paper 15459678 Paper 15148986 Paper 14622959 Paper 14522853 Paper 12970413 Paper 12837603 Paper 12738843 Paper 12704221 Paper 12692251 Paper 12594216 Paper 12551897 Paper 12424693 Paper 12196138 Paper 12082114 Paper 11701770 Paper 11581378 Paper 11471561 Paper 11450303 Paper 11447689 Paper 11375994 Paper 11295556 Paper 11279046 Paper 11214931 Paper 11157745 Paper 10970836 Paper 10888922 Paper 10811921 Paper 10775631

Abstract

Accomplishments for FY2011: 1) We have studied the structures of prion seeded recombinant PrP fibrils by infrared spectroscopy and solid-state nuclear magnetic resonance spectroscopy and found evidence for parallel-inregister beta sheet conformations in portions of those fibrils. 2) Using a combination of infrared and hydrogen-deuterium exchanges spectroscopies we have discriminated strain-dependent conformations of mouse scrapie prion protein and determined that the effects of glycosylation and GPI-anchoring on the conformations are modest relative to the conformational differences between strains.

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