Neuropathology Core

$159,461P30FY2011AGNIH

University Of California At Davis, Davis CA

Investigators

Linked publications & trials

Paper 39677464 Paper 39594552 Paper 39379761 Paper 39254167 Paper 39239892 Paper 39207439 Paper 39173101 Paper 38995966 Paper 38980643 Paper 38958543 Paper 38958117 Paper 38949538 Paper 38915636 Paper 38909025 Paper 38883718 Paper 38759012 Paper 38721926 Paper 38712163 Paper 38669550 Paper 38641585 Paper 38635941 Paper 38586023 Paper 38477469 Paper 38460116 Paper 38441951 Paper 38425303 Paper 38423160 Paper 38418871 Paper 38244935 Paper 38224546 Paper 38194584 Paper 38160359 Paper 38147416 Paper 38007645 Paper 37988169 Paper 37855140 Paper 37840499 Paper 37772658 Paper 37759924 Paper 37712765 Paper 37661877 Paper 37595405 Paper 37592813 Paper 37580727 Paper 37571345 Paper 37528055 Paper 37491248 Paper 37474615 Paper 37355729 Paper 37330193 Paper 37322115 Paper 37307817 Paper 37260021 Paper 37245492 Paper 37212114 Paper 37188790 Paper 37085326 Paper 37057867 Paper 37051669 Paper 37038809 Paper 37021572 Paper 36997127 Paper 36993352 Paper 36970907 Paper 36946449 Paper 36933278 Paper 36840665 Paper 36758620 Paper 36749884 Paper 36722399 Paper 36711704 Paper 36710669 Paper 36692190 Paper 36681388 Paper 36648159 Paper 36628434 Paper 36621368 Paper 36617779 Paper 36577280 Paper 36565204 Paper 36543124 Paper 36530083 Paper 36504357 Paper 36482861 Paper 36448771 Paper 36394443 Paper 36324086 Paper 36314203 Paper 36308307 Paper 36270451 Paper 36264254 Paper 36253382 Paper 36251929 Paper 36220593 Paper 36189595 Paper 36178120 Paper 36157332 Paper 36097795 Paper 36093697 Paper 36062452

Abstract

PROJECT SUMMARY (See Instructions): The Neuropathology Core (NPC) supports the clinical and research missions of the UCD ADC by providing (1) expert neuropathological (NP) analysis;and (2) well-preserved brain tissue, along with blood and DNA samples from the clinically well-characterized participants of our longitudinal cohort. In addition, the NPC plays an important role in bolstering basic and translational research on AD and related disorders by providing tissue samples, NP techniques, and NP tools. The UCD NPC has established expertise in postmortem NP analysis, with a special focus on assessment of vascular brain injury. The NPC works closely with the Clinical Core and the Neuroimaging Core to provide clinico-imaging-pathological correlation. The NPC works closely with the Data Management and Statistics Core to incorporate the NP data and tissue information to the web-based UCD ADC database, facilitating research. In collaboration with the Education and Information Transfer Core, the NPC promotes consenting to autopsy by our study subjects, and the use of the NPC resource for research. In the current funding period, we have accomplished all the proposed Aims. We have streamlined our brain and tissue procurement and processing procedures, and obtained more "research-grade" brain samples. We have collected and banked serum, plasma, and peripheral blood DNA from over 750 individuals participating in UCD ADC-sponsored research protocols. We have made substantial progress in obtaining minority autopsies. We have also developed new research tools such as tissue microarray and multiplex quantification method. Due to our enhanced infrastructure for research, the UCD NPC has become an essential player in the overarching UCD ADC research goal and have contributed to several multi-center projects involving sharing of neuropathological data and samples. Furthermore, there has been a substantial increase in the use of our biological samples by investigators within UCD and outside the ADC. and as a result we supported numerous grants and papers. In this reapplication. we propose to continue all the current aims, with new perspectives and opportunities building on the progress achieved during the current grant cycle.

View original record on NIH RePORTER →