Standardization of genetic testing for TEDDY screaning

National Institute Of Diabetes And Digestive And Kidney Diseases

Investigators

Abstract

The initial screen for recruitment into The Environmental Determinants of Diabetes in the Young (TEDDY) is identification of certain higher-risk haplotypes at HLA-DR and -DQ loci. Different centers will use different laboratory methods and algorithms to identify these higher-risk haplotypes. To insure between-center comparability in this screening, CDC will conduct annual qualification challenges using cord bloods and dried blood spots with pre-established reference haplotypes.